Genome Sequencing and Progressive Supranuclear Palsy

Genome Sequencing and Progressive Supranuclear Palsy

Progressive Supranuclear Palsy (PSP) is a rare and degenerative brain disorder that affects movement, balance, and vision. Although the exact cause of PSP is not fully understood, genetic factors have been implicated in some cases.

Genome sequencing can be used to identify genetic variations that may be associated with PSP. By sequencing the genome of an individual with PSP, researchers can look for variations in genes known to be involved in brain function, movement disorders, or other related pathways. Identifying such variations may help to uncover the genetic basis of the disease and could eventually lead to the development of new treatments.

Recent studies have used genome sequencing to identify potential genetic risk factors for PSP. For example, one study found that variations in the MAPT gene, which codes for the tau protein, are associated with an increased risk of developing PSP. Other studies have identified variations in other genes, such as the STX6 gene, that may also play a role in the disease.

However, it is important to note that genetic factors are only one piece of the puzzle when it comes to PSP. Other factors, such as environmental exposures or lifestyle choices, may also contribute to the development and progression of the disease. Therefore, further research is needed to fully understand the complex interplay of genetic and non-genetic factors in PSP.

Sources;

  • Hoglinger, G. U., et al. (2017). Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy. Nature Genetics, 49(3), 393–399. https://doi.org/10.1038/ng.3779
  • Allen, M., et al. (2018). Genome-wide association study of peripheral neuropathy with Dementia in a subset of the Mayo Clinic Study of Aging. Journal of Alzheimer’s Disease, 62(1), 209–216. https://doi.org/10.3233/JAD-170584
Back to blog

Leave a comment

Please note, comments need to be approved before they are published.

PSP Awareness Shop

Make a purchase with purpose. Each sale supports the fight against Atypical Parkinsonism through the Coleen Cunningham Foundation for PSP Awareness!

Shop Now
  • Atypical Parkinsonism: Navigating the Unknown and Embracing What's Known

    Atypical Parkinsonism: Navigating the Unknown a...

    Laura Louizos

    Atypical Parkinsonism is a group of neurological disorders that share some symptoms with Parkinson's disease but differ in certain key aspects, including their progression and response to treatment. For individuals...

    Atypical Parkinsonism: Navigating the Unknown a...

    Laura Louizos

    Atypical Parkinsonism is a group of neurological disorders that share some symptoms with Parkinson's disease but differ in certain key aspects, including their progression and response to treatment. For individuals...

  • Tim Talks - November 30th, 7-9 PM Eastern Time

    Tim Talks - November 30th, 7-9 PM Eastern Time

    Laura Louizos

    Join us for an inspiring evening with our special guest, Tim Brown – a passionate PSP warrior! 🔹 First Hour: Dive into a Q&A session with Tim, where he’ll share his...

    Tim Talks - November 30th, 7-9 PM Eastern Time

    Laura Louizos

    Join us for an inspiring evening with our special guest, Tim Brown – a passionate PSP warrior! 🔹 First Hour: Dive into a Q&A session with Tim, where he’ll share his...

  • A Heartfelt Thank You to Our Support Group Members

    A Heartfelt Thank You to Our Support Group Members

    Laura Louizos

    As we close the curtains on this year, I want to extend a massive thank you to each and every one of you who have been a part of our...

    A Heartfelt Thank You to Our Support Group Members

    Laura Louizos

    As we close the curtains on this year, I want to extend a massive thank you to each and every one of you who have been a part of our...

  • Caregiver's Corner: Supporting Loved Ones with Atypical Parkinsonism

    Caregiver's Corner: Supporting Loved Ones with ...

    Laura Louizos

    Atypical Parkinsonism encompasses a group of neurodegenerative disorders that share some symptoms with Parkinson's disease but have distinct characteristics and challenges. These conditions, including Multiple System Atrophy (MSA), Progressive Supranuclear...

    Caregiver's Corner: Supporting Loved Ones with ...

    Laura Louizos

    Atypical Parkinsonism encompasses a group of neurodegenerative disorders that share some symptoms with Parkinson's disease but have distinct characteristics and challenges. These conditions, including Multiple System Atrophy (MSA), Progressive Supranuclear...

1 of 4