Clinical Trials Investigating Potential Treatments for PSP

Clinical Trials Investigating Potential Treatments for PSP

Progressive supranuclear palsy (PSP) is a rare and progressive neurodegenerative disorder for which there is currently no cure. However, there are ongoing clinical trials investigating potential treatments for PSP. These trials aim to evaluate the safety and effectiveness of various drugs and therapies in reducing the symptoms of PSP and slowing its progression.

Some of the drugs that are being studied in clinical trials for PSP include:

  1. Tau protein inhibitors: PSP is characterized by the accumulation of abnormal tau protein in the brain. Tau protein inhibitors are drugs that target the tau protein and aim to reduce its accumulation. Some examples of tau protein inhibitors being studied in PSP trials include LMTX, TPI-287, and RO7105705.

  2. Anti-inflammatory drugs: Inflammation in the brain may contribute to the progression of PSP. Anti-inflammatory drugs, such as pioglitazone and dextromethorphan, are being investigated in clinical trials to see if they can reduce inflammation and slow down the progression of PSP.

  3. Glutamate modulators: Glutamate is a neurotransmitter that is involved in many brain functions, including learning and memory. However, excessive glutamate release can be toxic to brain cells, and may contribute to neurodegeneration in PSP. Glutamate modulators, such as riluzole and memantine, are being studied to see if they can reduce glutamate toxicity and improve symptoms in PSP patients.

  4. Stem cell therapy: Stem cells have the ability to differentiate into various types of cells, and may be able to repair damaged brain tissue in PSP. Clinical trials are underway to investigate the safety and effectiveness of stem cell therapy in treating PSP.

It is important to note that clinical trials for PSP are still in the early stages, and more research is needed to determine the safety and effectiveness of these treatments. If you or a loved one is interested in participating in a clinical trial for PSP, you should talk to your doctor and research clinical trials in your area.

Back to blog

1 comment

Interested in participating in these clinical trials.

Valerie Thomas

Leave a public comment:

Please note, comments need to be approved before they are published.

  • The Unseen Struggle: Advocating for Someone with Atypical Parkinsonism

    The Unseen Struggle: Advocating for Someone wit...

    Living with atypical Parkinsonism is a complex and often misunderstood journey—not just for the person experiencing it, but for those who love and care for them. Unlike classic Parkinson’s disease,...

    The Unseen Struggle: Advocating for Someone wit...

    Living with atypical Parkinsonism is a complex and often misunderstood journey—not just for the person experiencing it, but for those who love and care for them. Unlike classic Parkinson’s disease,...

  • Board of Directors at Coleen Cunningham Foundation 2025

    Board of Directors at Coleen Cunningham Foundat...

    Introducing the backbone of CCF—our Board of Directors! This carousel showcases the talented individuals guiding our organization forward. Each photo is paired with a brief look at their unique role...

    Board of Directors at Coleen Cunningham Foundat...

    Introducing the backbone of CCF—our Board of Directors! This carousel showcases the talented individuals guiding our organization forward. Each photo is paired with a brief look at their unique role...

  • Introducing Your Guide to Atypical Parkinsonism Care: A Lifeline for Caregivers

    Introducing Your Guide to Atypical Parkinsonism...

    We’re thrilled to announce the release of Your Guide to Atypical Parkinsonism Care: Understanding and Supporting Loved Ones with PSP, MSA, CBD, and DLB, a vital new resource for anyone...

    Introducing Your Guide to Atypical Parkinsonism...

    We’re thrilled to announce the release of Your Guide to Atypical Parkinsonism Care: Understanding and Supporting Loved Ones with PSP, MSA, CBD, and DLB, a vital new resource for anyone...

  • Understanding Caregiver Burnout and Atypical Parkinsonism: Finding Relief Through Respite and Vacation Grants

    Understanding Caregiver Burnout and Atypical Pa...

    Caring for a loved one with atypical parkinsonism—conditions like Progressive Supranuclear Palsy (PSP), Multiple System Atrophy (MSA), or Corticobasal Degeneration (CBD)—is a labor of love that often comes with immense...

    1 comment

    Understanding Caregiver Burnout and Atypical Pa...

    Caring for a loved one with atypical parkinsonism—conditions like Progressive Supranuclear Palsy (PSP), Multiple System Atrophy (MSA), or Corticobasal Degeneration (CBD)—is a labor of love that often comes with immense...

    1 comment
1 of 4