4R-Tau seeding activity unravels molecular subtypes in patients with Progressive Supranuclear Palsy

4R-Tau seeding activity unravels molecular subtypes in patients with Progressive Supranuclear Palsy

Here’s our simpler summary:

Researchers studied a condition called Progressive Supranuclear Palsy (PSP), which involves abnormal tau protein in the brain. They wanted to understand why some patients with PSP progress faster than others. To do this, they looked at the tau protein in 20 different areas of the brain in 25 PSP patients.

They discovered that a specific kind of tau, called HMW-Tau, was linked to the speed of disease progression. More of this HMW-Tau in the primary motor cortex (an area of the brain) was linked to faster disease progression. They also found out that the immune system played a role in the differences seen between patients.

They further studied where and how this HMW-Tau was present in the brain and noticed it varied between patients and even within different parts of the brain. In some patients, the presence of this HMW-Tau was linked to tau "clumps" or oligomers.

In short, the type and location of tau protein in the brain could be a reason why PSP progresses differently in patients.

Full Original Article-
doi: https://doi.org/10.1101/2023.09.28.559953
By: Ivan Martinez-Valbuena, Seojin Lee, Enrique Santamaria, Joaquin Fernandez Irigoyen, Shelley Forrest, Jun Li, Hidetomo Tanaka, Blas Couto, Nikolai Gil Reyes, Hania Qamar, Ali M Karakani, Ain Kim, Konstantin Senkevich, Ekaterina Rogaeva, Susan H Fox, Carmela Tartaglia, Naomi P Visanji, Tallulah Andrews, Anthony E Lang, Gabor Geza Kovacs

 

Back to blog

Leave a public comment:

Please note, comments need to be approved before they are published.

  • Merry Christmas or Not!

    Merry Christmas or Not!

    Laura Louizos

    The holiday season often arrives with an avalanche of emotions, especially for those of us carrying the weight of loss. The twinkling lights and cheerful gatherings can sometimes feel more...

    Merry Christmas or Not!

    Laura Louizos

    The holiday season often arrives with an avalanche of emotions, especially for those of us carrying the weight of loss. The twinkling lights and cheerful gatherings can sometimes feel more...

  • 2024 has been a year of growth and impact

    2024 has been a year of growth and impact

    Laura Louizos

    As we gather around the warmth of the holiday season, we want to extend our heartfelt thanks for your unwavering support and dedication throughout this remarkable year.2024 has been a...

    2024 has been a year of growth and impact

    Laura Louizos

    As we gather around the warmth of the holiday season, we want to extend our heartfelt thanks for your unwavering support and dedication throughout this remarkable year.2024 has been a...

  • Hummingbird Hope: A Year-End Call for Atypical Parkinsonism Support

    Hummingbird Hope: A Year-End Call for Atypical ...

    Laura Louizos

    As we approach the end of the year, we're reaching out to our community with a heartfelt plea for support. Your generosity can make a profound difference in the lives...

    Hummingbird Hope: A Year-End Call for Atypical ...

    Laura Louizos

    As we approach the end of the year, we're reaching out to our community with a heartfelt plea for support. Your generosity can make a profound difference in the lives...

  • Christmas Gifts for Loved Ones with Atypical Parkinsonism

    Christmas Gifts for Loved Ones with Atypical Pa...

    Laura Louizos

    As the holiday season approaches, choosing the perfect gift for someone living with atypical Parkinsonism, like Progressive Supranuclear Palsy (PSP), Multiple System Atrophy (MSA), or Corticobasal Degeneration (CBD), can be...

    1 comment

    Christmas Gifts for Loved Ones with Atypical Pa...

    Laura Louizos

    As the holiday season approaches, choosing the perfect gift for someone living with atypical Parkinsonism, like Progressive Supranuclear Palsy (PSP), Multiple System Atrophy (MSA), or Corticobasal Degeneration (CBD), can be...

    1 comment
1 of 4